Download a complete bibliography from each of our ongoing investigational programs below.
SPR720
Treatment of Mycobacterium avium subspecies hominissuis (MAH) infection with a novel gyrase inhibitor (SPR719/SPR720) was associated with a significant decrease in bacterial load as assessed in macrophages, biofilm and in mice
Tebipenem HBR
Antimicrobial activity assessment of tebipenem (SPR859) against an isolate collection causing urinary tract infections
Tebipenem HBR
In vitro bactericidal activity and post-antibiotic effect of tebipenem (SPR859) against susceptible and extended-spectrum beta-lactamase producing Enterobacteriaceae as compared to levofloxacin (LVX) and meropenem (MEM)
Tebipenem HBR
In vivo characterization of tebipenem-pivoxil (SPR994) in a murine ascending Escherichia coli urinary tract model
Tebipenem HBR
Characterization of the mechanism of action of tebipenem (SPR859) in the Escherichia coli macromolecular synthesis assay
Tebipenem HBR
In vitro activity of tebipenem (SPR859) against penicillin-binding proteins of gram-negative bacteria
Tebipenem HBR
Impact of varied test conditions on the in vitro activity of tebipenem (SPR859) and meropenem against urinary pathogens, including those expressing extended-spectrum beta-lactamases (ESBL)
Tebipenem HBR
Frequency of spontaneous mutations conferring reduced susceptibility to tebipenem (SPR859) among susceptible and extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae
Tebipenem HBR
In vivo efficacy of tebipenem-pivoxil (SPR994) in an acute murine thigh infection caused by Escherichia coli and Klebsiella pneumoniae
Tebipenem HBR
In vitro activity of tebipenem (SPR859), tebipenem-pivoxil (SPR994) and meropenem against a broad spectrum of anaerobic bacteria
Tebipenem HBR
Antimicrobial activity of tebipenem (SPR859) against a global challenge set of Enterobacteriaceae isolates
Rex JH, Talbot GH, Goldberger MJ, et al. Progress in the Fight Against Multidrug-Resistant Bacteria 2005-2016: Modern Noninferiority Trial Designs Enable Antibiotic Development in Advance of Epidemic Bacterial Resistance. Clin Infect Dis. 2017 Jul 1;65(1):141-146.
Pucci MJ, Dougherty TJ. Editorial overview: Antimicrobials: fighting bacterial infections in the 21st century-thinking outside of the box. Curr Opin Microbiol. 2016 Oct;33:v-vii
SPR206
Zabawa TP, Pucci MJ, Parr TR Jr, Lister T. Treatment of Gram-negative bacterial infections by potentiation of antibiotics. Curr Opin Microbiol. 2016 Oct;33:7-12.
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Download a complete bibliography from each of our ongoing investigational programs below.
