Top tier talent. Meaningful work.
An audacious mission.

Learn why Spero has been named one of the 2024 Best Places to Work by the Boston Business Journal. Our highly experienced and uniquely qualified team of biotechnology and biopharmaceutical experts is led by President and CEO, Sath Shukla.

Openly transparent and highly respectful, our leadership team firmly believes that Spero Therapeutics’ employees are their most important and valued resource.

2024 Best place to work
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Career opportunities

Biopharmaceutical Jobs That Offer Hope to a World in Need
An opportunity to work on critical global health issues backed by the support of a strong leadership team that genuinely cares about your professional development and success.

Job Applicant Alert
Please be aware of potentially fraudulent job postings or suspicious recruiting activity by persons posing as recruiters or agents on behalf of potential employers, including Spero Therapeutics, Inc. These scammers may attempt to collect your confidential personal or financial information. If you are concerned that an offer of employment with Spero Therapeutics, Inc. might be a scam or that the recruiter is not legitimate, please verify by searching for the posting on the Career site:

Spero Therapeutics, Inc. will not conduct interviews nor attempt to collect your confidential personal or financial information via text message or messaging platforms and will not ask you to download anything as part of your interview. Though we use third-party tools to help advertise our jobs, please be vigilant in checking that the communication comes from Spero Therapeutics, Inc.

If you received what you believe is a fake offer letter and provided any personal information or made purchases as part of a fraudulent offer process, we recommend you immediately contact the FBI Internet Crime Complaint Center at

Life at Spero

Spero employees are passionate about antibiotic drug development and the mission of delivering life-saving drugs to patients suffering from multidrug-resistant infections and rare diseases. The need for more agents is greater than ever before to treat patients for whom there are no generic options. Consider too that the rate of mortality for resistant organisms is the equivalent of one Boeing 747 “Jumbo Jet” crashing each week.

We’ve built an organization on foundations of stability, momentum and commitment to excellence. Spero’s future hinges on the success + proper stewardship of our current arsenal, as well as shaping the conversation to educate the public on the ability of these drugs to keep people out of the hospital.

By joining our committed and highly motivated team, you’ll experience a workplace culture that is inclusive, fair, challenging, supportive, and respectful. Spero’s culture is one that emphasizes “servant leadership,” or putting ego aside and working for the benefit of the team and our patients, and values our colleagues’ opinions and celebrates accomplishments in service of patients. At Spero, we want our employees to learn and grow, and look for ways to help develop skills through industry, company and functional training, as well as mentoring.

Our Values:
Be Audacious. Be Humble. Be the Expert. Be Engaged. Do Good.

image collage of spero's executive team members

Why Join Spero

At Spero Therapeutics, it’s our determined hope to become the leader in advancing novel treatments for serious infections and we are always looking for new talent to help us accomplish this mission. We hope you’ll consider joining us on an exciting and rewarding journey of discovery and career fulfillment.

Employees have the support of industry leaders, who have had over 175 years of combined experience, including the approval of 11 new antibacterials. Our leadership team is approachable and transparent while encouraging of open lines of communication which, in turn, leads to confidence and a high degree of camaraderie built on a solid foundation of trust.

SPERO Benefits

Spero Therapeutics offers a competitive benefits package that includes:
  • Medical, Dental and Vision Insurance Coverage
  • Life and AD&D Coverage
  • Short- and Long-Term Disability Insurance Coverage
  • 401(k) Plan with Company Match
  • Flexible Work Environment

Work With Us

Named one of Boston’s Best Places to Work in 2024, 2021, 2020, and 2017, Spero Therapeutics was also the recipient of the first-ever 2017 Xconomy Startup of the Year Award. As proud as we are of these achievements, we’re even more grateful for the talented and extraordinary people with experience in infectious disease who have chosen to join us in our pursuits. We encourage you to take the time to learn more about us. We look forward to learning more about you and your career interests in Spero Therapeutics!

Spero Therapeutics provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

2024 Best place to work

About Spero

Spero Therapeutics is committed to advancing novel treatment approaches for bacterial infections.  Our world-class team of biotechnology and biopharmaceutical experts embraces the Italian word “spero” which means “hope.” It is our mission to bring hope to patients and families of loved ones suffering from serious infections.

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