Download a complete bibliography from each of our ongoing investigational programs below.
Tebipenem HBR
Population pharmacokinetic analyses for tebipenem after the administration of tebipenem pivoxil hydrobromide
Tebipenem HBR
A validated sensitive and selective ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for quantitative analysis of tebipenem pivoxil and tebipenem, in human whole blood and its application in a pharmacokinetic study in healthy human volunteers
Tebipenem HBR
Pharmacokinetics of oral tebipenem pivoxil hydrobromide in subjects with varying degrees of renal impairment
Tebipenem HBR
Activity of tebipenem against a set of recent clinical isolates from urinary tract and upper respiratory tract infections
Tebipenem HBR
In vitro minimum inhibitory and minimum bactericidal concentrations of tebipenem and comparators against contemporary Enterobacterales tested in pooled human urine at varied pH
Tebipenem HBR
Agar dilution versus broth microdilution of tebipenem against ESBL-producing Enterobacterales
Tebipenem HBR
Gupta VK, Maier G, Eckburg P, et al. A randomized, double-blind, placebo- and positive-controlled crossover study of the effects of tebipenem pivoxil hydrobromide on QT/QTc intervals in healthy subjects. Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0014521.
Tebipenem HBR
Lodise TP, Chopra T, Nathanson BH, Sulham K. Hospital admission patterns of adult patients with complicated urinary tract infections who present to the hospital by disease acuity and comorbid conditions: How many admissions are potentially avoidable? Am J Infect Control. 2021 May 30:S0196-6553(21)00382-5.
Tebipenem HBR
Hospital admission patterns in adult patients with complicated urinary tract infections: identification of potentially avoidable hospital admissions across US hospitals
Tebipenem HBR
Eligibility and outcomes of conversion to oral (PO) therapy in patients hospitalized with Enterobacteriaceae (ENT) urinary tract infection (UTI) in the United States (US): a multicenter analysis
Tebipenem HBR
Clinical characteristics and demographics of patients with complicated urinary tract infections (cUTI) and antibiotic resistance or treatment failure: a retrospective database analysis
Tebipenem HBR
Epidemiology of complicated urinary tract infections (cUTIs) presenting in emergency departments across the United States (US)
Tebipenem HBR
Tebipenem: An oral carbapenem with activity against multi-drug resistant urinary tract infection isolates of Escherichia coli collected from US medical centers during 2019
Tebipenem HBR
Health resource utilization in patients with complicated urinary tract infections (cUTI) and antibiotic resistance or treatment failure: a retrospective database analysis
Tebipenem HBR
Oral tebipenem pivoxil hydrobromide is non-inferior to IV ertapenem in complicated urinary tract infection (cUTI) and acute pyelonephritis (AP) – Results from the pivotal ADAPT-PO study.
SPR206
Brown P, Abdulle O, Boakes S, et al. Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin. ACS Infect Dis. 2021 Apr 9;7(4):894-905.
Tebipenem HBR
Clayton NP, Jain A, Halasohoris SA, et al. In vitro and in vivo characterization of tebipenem (TBP), an orally active carbapenem, against biothreat pathogens. Antimicrob Agents Chemother. 2021 Feb 16:AAC.02385-20.
Tebipenem HBR
Zilberberg MD, Nathanson BH, Sulham K, Shorr AF. Multiple antimicrobial resistance and outcomes among hospitalized patients with complicated urinary tract infections in the US, 2013-2018: a retrospective cohort study. BMC Infect Dis. 2021 Feb 8;21(1):159.
Tebipenem HBR
Critchley IA, Cotroneo N, Pucci MJ, Jain A, Mendes RE. Resistance among urinary tract pathogens collected in Europe during 2018. J Glob Antimicrob Resist. 2020 Dec;23:439-444.
Tebipenem HBR
Characterization of tebipenem pivoxil hydrobromide pharmacokinetics-pharmacodynamics in a neutropenic murine acute pyelonephritis model
Tebipenem HBR
Clinical characteristics and demographics of patients with complicated urinary tract infections (cUTI) and antibiotic resistance or treatment failure: a retrospective database analysis
Tebipenem HBR
Hospital costs and reimbursement in patients with resistant Enterobacteriaceae (ENT) urinary tract infection (UTI) in the United States (US): a multicenter analysis
Tebipenem HBR
Oral tebipenem pivoxil hydrobromide is non-inferior to IV ertapenem in complicated urinary tract infection (cUTI) and acute pyelonephritis (AP) – Results from the pivotal ADAPT-PO study.
Tebipenem HBR
Epidemiology of complicated urinary tract infections (cUTIs) presenting in emergency departments across the United States (US)
Tebipenem HBR
Health resource utilization in patients with complicated urinary tract infections (cUTI) and antibiotic resistance or treatment failure: a retrospective database analysis
Tebipenem HBR
Tebipenem: An oral carbapenem with activity against multi-drug resistant urinary tract infection isolates of Escherichia coli collected from US medical centers during 2019
Tebipenem HBR
Pre and post hospitalization resource utilization and costs associated with urinary tract infection (UTI) in both commercial and Medicare populations
Tebipenem HBR
Eligibility and outcomes of conversion to oral (PO) therapy in patients hospitalized with Enterobacteriaceae (ENT) urinary tract infection (UTI) in the United States (US): a multicenter analysis
Tebipenem HBR
Hospital admission patterns in adult patients with complicated urinary tract infections: identification of potentially avoidable hospital admissions across US hospitals
Tebipenem HBR
Cotroneo N, Rubio A, Critchley IA, et al. In vitro and in vivo characterization of tebipenem, an oral carbapenem. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e02240-19.
Tebipenem HBR
Zilberberg MD, Nathanson BH, Sulham K, Shorr AF. Antimicrobial Susceptibility and Cross-Resistance Patterns among Common Complicated Urinary Tract Infections in U.S. Hospitals, 2013 to 2018. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00346-20.
Tebipenem HBR
Epidemiology, empiric treatment, and outcomes among hospitalized patients with complicated urinary tract infections in the US, 2013-2018
Tebipenem HBR
Resistance to oral antibiotics among urinary tract infection isolates of Escherichia coli from the United States and Europe in 2017
Tebipenem HBR
Antimicrobial susceptibility patterns of common complicated urinary tract infection pathogens in US Hospitals, 2013-2018
Tebipenem HBR
Characterization of tebipenem pharmacokinetics-pharmacodynamics for efficacy against Enterobacteriaceae in a one-compartment in vitro infection model
SPR206
Akhoundsadegh N, Belanger CR, Hancock REW. Outer Membrane Interaction Kinetics of New Polymyxin B Analogs in Gram-Negative Bacilli. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00935-19.
Tebipenem HBR
Single- and multiple-ascending dose (SAD/MAD) study demonstrates the human pharmacokinetics (PK) and tolerability of SPR994 (tebipenem pivoxil hydrobromide), an oral carbapenem (CP), at the predicted therapeutic dose
Tebipenem HBR
Eckburg PB, Jain A, Walpole S, et al. Safety, pharmacokinetics, and food effect of tebipenem pivoxil hydrobromide after single and multiple ascending oral doses in healthy adult subjects. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00618-19.
Tebipenem HBR
McEntee L, Johnson A, Farrington N, et al. Pharmacodynamics of tebipenem: New options for oral treatment of multidrug-resistant gram-negative infections. Antimicrob Agents Chemother. 2019 Jul 25;63(8): e00603-19.
Tebipenem HBR
The burden of resistance among urinary tract isolates of Escherichia coli in the United States in 2017
Tebipenem HBR
Monitoring the in vitro activity of tebipenem, an orally available carbapenem agent, against a current collection of surveillance Enterobacteriaceae clinical isolates (2018)
Tebipenem HBR
SPR994: oral carbapenem for the treatment of complicated urinary tract infections
Tebipenem HBR
Evaluation of tebipenem activity tested against a collection of isogenic Escherichia coli strains producing various clinically relevant β-lactamases
SPR720
In vitro activity of SPR719 against non-Tuberculosis Mycobacterium strains of Mycobacterium ulcerans, Mycobacterium marinum, and Mycobacterium chimaera - pipeline drugs to treat
Tebipenem HBR
Single-and multiple-ascending dose (SAD/MAD) study demonstrates the human pharmacokinetics (PK) and tolerability of SPR994 (tebipenem pivoxil hydrobromide), an oral carbapenem (CP), at the predicted therapeutic dose
SPR720
In vitro activity of SPR719 against non-Tuberculosis Mycobacterium strains of Mycobacterium ulcerans, Mycobacterium marinum, and Mycobacterium chimaera
Tebipenem HBR
Arends SJR, Rhomberg PR, Cotroneo N, et al. Antimicrobial activity evaluation of tebipenem (SPR859), an orally available carbapenem, against a global set of Enterobacteriaceae isolates, including a challenge set of organisms. Antimicrob Agents Chemother. 2019 May 24;63(6):e02618-18.
Tebipenem HBR
Escherichia coli from urinary tract infections in Europe in 2017 are increasingly multidrug-resistant to oral antibiotics in an era of co-resistance to extended-spectrum beta-lactamases
Tebipenem HBR
Activity of tebipenem, an oral carbapenem, against multidrug-resistant urinary tract infection-causing pathogens with characterized resistance mechanisms collected in Europe and the United States in 2016
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Download a complete bibliography from each of our ongoing investigational programs below.
